Obesity and Insulin Resistance in Childhood.
10.12701/yujm.2012.29.2.73
- Author:
Kwang Hae CHOI
1
Author Information
1. Department of Pediatrics, College of Medicine, Yeungnam University, Daegu, Korea. ckh@med.yu.ac.kr
- Publication Type:Review
- Keywords:
Childhood obesity;
Insulin resistance;
hypertension;
Non-alcoholic steatohepatitis;
Polycystic ovarian syndrome
- MeSH:
Acanthosis Nigricans;
Adipokines;
Child;
Cytokines;
Diabetes Mellitus, Type 2;
Diet;
Dyslipidemias;
Energy Metabolism;
Fatty Liver;
Humans;
Hypertension;
Insulin;
Insulin Resistance;
Interleukin-6;
Leptin;
Metabolic Diseases;
Obesity;
Overweight;
Polycystic Ovary Syndrome;
Resistin;
Tumor Necrosis Factor-alpha
- From:Yeungnam University Journal of Medicine
2012;29(2):73-76
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
More and more children are becoming obese and overweight due to several factors that include a high energy density in the diet (a high fat intake) and low energy expenditure. Consequently childhood obesity is becoming a significant health problem. Fat tissue releases many cytokines such as resistin, tumor necrosis factor-alpha, leptin, interleukin-6. These adipocytokines induce obesity-related insulin resistance. Insulin resistance is a key component of obesity-related metabolic problems such as hypertension, type 2 diabetes mellitus, dyslipidemia, non-alcoholic steatohepatitis, acanthosis nigricans and polycystic ovarian syndrome. This review article focused on insulin resistance and its related metabolic diseases.
