Increased expression of pAKT is associated with radiation resistance in cervical cancer.
- Author:
Tae Joong KIM
1
;
Jeong Won LEE
;
Sang Yong SONG
;
Jung Joo CHOI
;
Chel Hun CHOI
;
Byoung Gie KIM
;
Je Ho LEE
;
Duk Soo BAE
Author Information
1. Department of Obstetrics and Gynecology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea. ds123.bae@samsung.com
- Publication Type:Original Article
- Keywords:
Cervical neoplasms;
Radiation resistance;
Local recurrence;
pAKT;
Immunohistochemistry
- MeSH:
Disease-Free Survival;
Female;
Humans;
Immunohistochemistry;
Negative Staining;
Recurrence;
Retrospective Studies;
Uterine Cervical Neoplasms*
- From:Korean Journal of Gynecologic Oncology
2006;17(1):33-38
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
OBJECTIVE: The aim of this study was to investigate the association of phosphorylated AKT (pAKT) expression and radiation resistance in cervical cancer. METHODS: A retrospective review was made of the records of 25 women who received primary radiation therapy due to locally advanced cervical cancer (LACC) with FIGO stage IIB-IVA. Nine patients regarded as radiation resistant developed local recurrences with a median progression free interval of 10 months. Sixteen patients did not show local recurrences, and were regarded as a radiation sensitive group. Using pretreatment paraffin-embedded tissues, we evaluated pAKT expression by immunohistochemistry. RESULTS: A significant association was found between the level of pAKT expression and local recurrence. Immunohistochemical staining for pAKT was significantly more frequent in the radiation resistant than in the radiation sensitive group (p=0.007). The mean progression free survival (PFS) was 84 months for patients with pAKT negative staining (17 cases) and 44 months for patients with pAKT positive expression (8 cases)(p=0.015). CONCLUSION: These results suggest that signaling from PI3K/pAKT can lead to radiation resistance in LACC.
