Cutaneous Mucormycosis in a Patient with Diabetes Mellitus.
10.12771/emj.2016.39.1.10
- Author:
Ji Hwan PARK
1
;
Seo Hwa PARK
;
Eun Gyu KANG
;
Gyu Cheon KYUNG
;
Hyo Dong AN
;
So Yeon AN
Author Information
1. Department of Internal Medicine, Hongik Hospital, Seoul, Korea. yeonigge00@naver.com
- Publication Type:Case Report
- Keywords:
Mucormycosis;
Diabetes mellitus;
Trauma;
Amputation;
Liposomal amphotericin B
- MeSH:
Acidosis;
Aged;
Amphotericin B;
Amputation;
Antifungal Agents;
Biopsy;
Burns;
Deferoxamine;
Diabetes Mellitus*;
Female;
Fungi;
Hematologic Neoplasms;
Humans;
Hyphae;
Leg;
Lung;
Motor Vehicles;
Mucormycosis*;
Neutropenia;
Organ Transplantation;
Rare Diseases;
Risk Factors;
Skin;
Transplants
- From:The Ewha Medical Journal
2016;39(1):10-13
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Mucormycosis is a rare disease caused by fungi. Most commonly involved sites of mucormycosis infection are sinuses, lungs, skin and soft tissues. Systemic risk factors for mucormycosis are diabetes mellitus, neutropenia, corticosteroid use, hematological malignancies, organ transplantation, metabolic acidosis, deferoxamine use and advanced age. Local risk factors are history of trauma, burns, surgery and motor vehicle accidents. We present a case of cutaneous mucormycosis in a patient with diabetes mellitus. A 66-year-old female with uncontrolled diabetes mellitus, admitted with necrotizing lesion after minor abrasions on leg. We took a culture of the lesion and it is diagnosed with mucormycosis. Disease progressed despite administration of systemic amphotericin B. We performed above-knee amputation and changed antifungal agents into liposomal amphotericin B. A tissue biopsy showed nonseptate, irregularly wide fungal hyphae with frequent right-angle branching. Our case report suggests that patients with risk factors should be observed carefully.
