Clinical Characteristics of Acute Aortic Syndrome in Korean Patients: From the Korean Multi-Center Registry of Acute Aortic Syndrome.
10.4070/kcj.2012.42.8.528
- Author:
Jung Rae CHO
1
;
Sanghoon SHIN
;
Jung Sun KIM
;
Young Guk KO
;
Myeong Ki HONG
;
Yangsoo JANG
;
Ki Bae SEUNG
;
Hun Sik PARK
;
Seung Jea TAHK
;
Do Sun LIM
;
Dong Wun JEON
;
In Ho CHAE
;
Duk Kyung KIM
;
Junghan YOON
;
Myung Ho JEONG
;
Donghoon CHOI
Author Information
1. Cardiology Division, Kangnam Sacred Heart Hospital, Hallym University College of Medicine, Seoul, Korea.
- Publication Type:Multicenter Study ; Original Article
- Keywords:
Aortic diseases;
Dissection;
Hematoma;
Population characteristics
- MeSH:
Aneurysm, Dissecting;
Aortic Diseases;
Back Pain;
Follow-Up Studies;
Hematoma;
Humans;
Hypertension;
Medical Records;
Population Characteristics;
Prognosis;
Pyridines;
Retrospective Studies;
Risk Factors;
Thiazoles;
Thorax;
Ulcer
- From:Korean Circulation Journal
2012;42(8):528-537
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND AND OBJECTIVES: Acute aortic syndrome (AAS) is a heterogeneous group of disorders that often present with severe chest or back pain. It includes acute aortic dissection (AD), intramural hematoma (IMH), dissecting aneurysm, and penetrating aortic ulcer (PAU). The clinical picture of AAS and its prognosis have not been studied in a large number of Korean patients. Therefore, we organized a multi-center registry to identify the clinical characteristics and treatment patterns, as well as long-term outcomes in Korean patients with AAS. SUBJECTS AND METHODS: Five-hundred twenty-eight patients, who had been diagnosed with AAS, were enrolled into this registry from 10 centers. On a retrospective basis, we collected demographic, laboratory, imaging data, as well as follow-up clinical outcomes by reviewing medical records from individual centers. All the data were collected in core lab and analyzed in detail. RESULTS: The mean patient age was 60.1+/-14.5 years; the male-to-female ratio was M : F=297 : 231. The prevalent risk factors for AAS included hypertension (361, 68.4%) and diabetes (52, 11.1%). The components of AAS that are included in this study are acute AD (446, 84.5%), IMH (57, 10.7%), and PAU (11, 2.1%). By type of AAS, patients diagnosed with Stanford A were 45.6% of enrolled patients, whereas those with Stanford B were 54.4% of enrolled patients. Among nearly half of the patients were treated with medicine (55.7%) alone, whereas 40.0% underwent surgery and 4.3% underwent endovascular treatment. Overall, the in-hospital event rate was 21.2% and the in-hospital death rate was 8.1%. The mean follow-up duration was 42.8 months and there showed 22.9% of total event and 10.1% of death during this period. CONCLUSION: By organizing a multi-center registry of AAS, we could identify the characteristics of AAS in real-world Korean patients. Further, prospective study is warranted with a larger number of patients.
