Expression of Glucagon-Like Peptide-1 Receptor in Papillary Thyroid Carcinoma and Its Clinicopathologic Significance.
10.3803/EnM.2014.29.4.536
- Author:
Min Jung JUNG
1
;
Su Kyoung KWON
Author Information
1. Department of Pathology, Kosin University Gospel Hospital, Kosin University College of Medicine, Busan, Korea.
- Publication Type:Original Article
- Keywords:
Glucagon-like peptide-1 receptor;
Thyroid cancer, papillary;
Incretin-based therapy;
Clinical significance
- MeSH:
Cell Proliferation;
Cytoplasm;
Glucagon-Like Peptide 1*;
Hyperplasia;
Lymph Nodes;
Medical Records;
Neoplasm Metastasis;
Retrospective Studies;
Thyroid Gland;
Thyroid Neoplasms*;
Glucagon-Like Peptide-1 Receptor
- From:Endocrinology and Metabolism
2014;29(4):536-544
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND: Incretin-based therapies are rapidly becoming one of the main glycemic control strategies in diabetes. Considering the large numbers of papillary thyroid carcinomas (PTCs) and possible effects of glucagon-like peptide-1 (GLP-1) on cell proliferation, the expression of GLP-1 receptor (GLP-1R) in PTC is likely to have clinical significance. We performed this study to evaluate the expression of GLP-1R in PTC and the clinical meaning of GLP-1R expression in PTC. METHODS: Fifty-six cases of PTC, four cases of medullary thyroid cancer (MTC), seven cases of nodular hyperplasia and 56 normal thyroid tissue samples were selected for immunostaining for GLP-1R. Clinical parameters were obtained by retrospective review of medical records. RESULTS: Immunohistochemical staining for GLP-1R showed immunoreactivity in 18 of 56 cases of PTC (32.1%). All four cases of MTC exhibited cytoplasmic GLP-1R expression. Nodular hyperplasia exhibited immunoreactivity in two of seven cases (28.6%). All normal thyroid follicular cells showed negative immunoreactivity. In univariable and multivariable analyses, tumor multifocality was negatively correlated with GLP-1R expression. Extrathyroidal extension showed positive association with GLP-1R expression that was almost significant. Sex, age, tumor size, and lymph node metastasis were not significantly associated with GLP-1R expression. CONCLUSION: Some parts of PTC tissues express GLP-1R, and GLP-1R expression in PTC was negatively correlated with tumor multifocality. The long-term influence of pharmacologically increased GLP-1 on thyroid follicular cells and development and progression of tumors originating from thyroid follicular cells should be investigated.
