Asthma Development Partially Linked to Adiponectin and Leptin in Overweight Children.
- Author:
Hey Sung BAEK
1
;
Young Dae KIM
;
Young Soon PARK
;
Jeh Hoon SHIN
;
Jae Won OH
;
Ha Baik LEE
Author Information
1. Department of Pediatrics, College of Medicine, Hanyang University, Seoul, Korea. halee@hanyang.ac.kr
- Publication Type:Original Article
- Keywords:
Asthma;
Overweight;
Child;
Leptin;
Adiponectin
- MeSH:
Adiponectin;
Aged;
Aluminum Hydroxide;
Antioxidants;
Asthma;
Biomarkers;
Body Mass Index;
Bronchial Provocation Tests;
Carbonates;
Child;
Diet;
Eosinophils;
Humans;
Immunoglobulin E;
Inhalation;
Insulin-Like Growth Factor Binding Protein 3;
Interleukin-6;
Interleukins;
Leptin;
Methacholine Chloride;
Micronutrients;
Obesity;
Overweight;
Prevalence;
Surveys and Questionnaires;
Running;
Tumor Necrosis Factor-alpha
- From:Pediatric Allergy and Respiratory Disease
2010;20(1):48-58
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: The prevalence of asthma and obesity is increasing concomitantly, but the link between asthma and obesity is unclear. We sought to address possible roles of leptin and adiponectin in the development of asthma, and changes in pulmonary function in overweight children. METHODS: Four study groups of 61 children aged 6 to 18 years (mean age, 9.69+/-2.16) were enrolled: (1) 14 mild-to-moderate asthmatics with overweight, (2) 16 mild-to-moderate asthmatics with normal weight, (3) 16 obese subjects without asthma, and (4) 15 healthy controls. We measured biomarkers in blood, including total and allergen-specific IgE, eosinophil, eosinophilc cationic protein (ECP), leptin, adiponectin, interleukin (IL)-6, tumor necrosis factor-alpha (TNF-alpha), lipid profiles, insulin-like growth factor-1 (IGF-1) and insulin-like growth factor binding protein 3 (IGF-BP3). Body mass index (BMI), antioxidants and micronutrients in a daily diet were evaluated by the questionnaire. We performed the bronchial challenge test by methacholine inhalation and free running, respectively. RESULTS: The leptin levels was apparently high, and the adiponectin level was low in the over-weight children, as depicting a significant inverse correlation between the 2 variables (R=-0.479; P<0.001). The FEV(1)/FVC ratio was low in the overweight children regardless of the presence of asthma. However, the effect of IL-6, TNF-alpha, nutrients, and other variables on asthma development in the overweight children with asthma was not verified. CONCLUSION: In this study, the levels of leptin, adiponectin or other obesity-related biomarkers were not independently associated with asthma. Therefore, it is concluded that obesity may not be an important factor in pulmonary function impairment.
