The Effect of Subconjunctival Injection of Liposome Encapsulated Cytarabine on Proliferation of Fibroblasts.
- Author:
Gong Je SEONG
1
;
Young Jae HONG
;
Seong Jun PARK
Author Information
1. Department of Ophthalmology, Yonsei University College of Medicine, Korea.
- Publication Type:Original Article
- Keywords:
Cytarabine;
Fibroblast;
Liposome encapsulated cytarabine
- MeSH:
Conjunctiva;
Culture Media;
Cytarabine*;
Fibroblasts*;
Liposomes*
- From:Journal of the Korean Ophthalmological Society
1992;33(9):885-891
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
To know the effect of subconjunctival injection of liposome encapsulated cytarabine on proliferation of conjunctival fibroblasts, the conjunctiva was isolated at 180 degrees from the injection site 3 days after subconjunctival injection of the normal saline (control), cytarabine, liposome encapsulated cytarabine, and 1 day after injection of cytarabine, and then those were inoculated in the culture media of fibroblasts. In the case of 3 days after injection of cytarabine, there was 49% and 42% inhibition of proliferation of conjunctival fibroblasts compared with the control respectively. Therefore, the authors concluded that the liposome encapsulated cytarabine is effective on inhibition of proliferation of conjunctival fibroblasts and reduces the frequencies of subconjunctival injection compared with the cytarabine itself.
