Significance of PCNA Oncoprotein as a Prognostic Predictor for Human Breast Cancer.
- Author:
Hyung Jun KIM
1
;
Se Heon CHO
;
Min Chan KIM
;
Young Hoon KIM
;
Ghap Joong JUNG
;
Sang Soon KIM
;
Sook Hee HONG
Author Information
1. Department of Surgery, Dong-A University, College of Medicine, Pusan, Korea.
- Publication Type:Original Article
- Keywords:
Proliferating cell nuclear antigen;
Breast cancer
- MeSH:
Antibodies, Monoclonal;
Breast Neoplasms*;
Breast*;
Humans*;
Neoplasm Metastasis;
Prognosis;
Proliferating Cell Nuclear Antigen*
- From:Journal of the Korean Surgical Society
1999;57(2):180-188
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: Many studies of PCNA (proliferating cell nuclear antigen) as a prognostic factor of breast cancer have been done recently. The aim of this study was to evaluate the relation between expression of PCNA and poor prognosis for a patient with breast cancer. METHODS: Immunohistochemical staining for PCNA was performed on sections from paraffin- embedded tissue blocks of 96 primary breast-cancer patients who were operated on at our hospital. We investigated the correlation between the traditional prognostic factors (patient age, primary tumor size, axillary lymph-node metastasis, pathological grade, and hormonal receptors) and PCNA expression. RESULTS: Statistically, the PCNA expression was not correlated with patient age, primary tumor size, menopausal state, pathologic grade, axillary lymph-node metastasis, or hormonal receptor (P>0.05). Thus a correlation between expression of PCNA and poor prognosis for breast cancer was not found in this study. CONCLUSIONS: More research using other monoclonal antibodies is needed to evaluate the relationship between expression of PCNA and the prognosis for breast cancer.
