Dentatorubro-pallidoluysian Atrophy: The Clinical and Molecular Genetic Study of Three Korean Families.
- Author:
Yeong Hee BAE
1
;
Joo Hyuk IM
;
Sang Ahm LEE
;
Sung Sup PARK
;
Myoung Chong LEE
Author Information
1. Department of Neurology, University of Ulsan, College of Medicine, Asan Medical Center.
- Publication Type:Case Report
- Keywords:
DRPLA, Triple repeats;
Neurodegenerative diseases;
Programmed cell death
- MeSH:
Age of Onset;
Anticipation, Genetic;
Atrophy*;
Chromosomes, Human, Pair 12;
Diagnosis;
Genes, vif;
Humans;
Molecular Biology*;
Neurodegenerative Diseases;
Phenotype;
Trinucleotide Repeats
- From:Journal of the Korean Neurological Association
2000;18(4):465-468
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Dentatorubro-pallidoluysian atrophy (DRPLA) is a rare neurodegenerative disorder with various clinical phenotypes and has a cytosine-adenine-guanine (CAG) trinucleotide repeat in a gene on chromosome 12. It has been known that trinucleotide repeat disorders show strong inverse correlations between the CAG repeat number and the age of onset and genetic anticipation. The purpose of this study was to investigate whether these observations are applicable to Korean patients. This report involved three Korean families and had on file the history of the 15 affected family mem-bers .Seven of the affected members had the diagnosis of DRPLA which was confirmed by a gene study. We observed inverse correlations between the CAG repeat number and the age of onset and genetic anticipation with high intra- and interfamilial variations. Although our study was in general agreement with previously documented features of DRPLA, some features could not be explained by currently understood pathophysiologic mechanisms.
