Two Cases of Pisa Syndrome Due to Cholinestrase Inhibitor.
- Author:
Yong Tae KWAK
1
;
Il Woo HAN
;
Jongsam BAIK
Author Information
1. Department of Neurology, Yong-in Hyoja Geriatric Hospital, Yong In Public Health Center.
- Publication Type:Case Report
- Keywords:
Cholinesterase inhibitor;
Alzheimer disease;
Pisa
- MeSH:
Acetylcholine;
Alzheimer Disease;
Cholinesterases;
Female;
Head;
Humans;
Movement Disorders;
Neck
- From:Journal of the Korean Neurological Association
2000;18(4):469-471
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
The Pisa syndrome is a rare extrapyramidal side effect with twisting and bending characteristics of the upper trunk, neck, and head, usually caused by neuroleptic treatment. However, there have been no reports of Pisa syndrome in cholinesterase inhibitor therapy. We report 2 female patients of Alzheimer's disease with Pisa syndrome after cholinesterase inhibitor ther-apy. The postural disturbance in these patients was completely resolved after the cessation of the cholinesterase inhibitor. Although the pathophysiology of Pisa syndrome appears to be extremely complicated and poorly understood, it may be of importance to consider the relationship between acetylcholine and Pisa syndrome. Therefore, the present cases provide a novel viewpoint on the underlying mechanism of the Pisa syndrome and the role of acetylcholine in the movement disorder.
