Two Cases of CD34-positive Glomus Tumors with Myxoid Stromal Changes.
- Author:
Hyun Woo KIM
1
;
Jun Oh PAEK
;
Ho Song KANG
;
Joung Soo KIM
;
Hee Joon YU
Author Information
1. Department of Dermatology, Hanyang University College of Medicine, Seoul, Korea. yuhjoon@hanyang.ac.kr
- Publication Type:Case Report
- Keywords:
CD34;
Glomus tumor;
Myxoid
- MeSH:
Actins;
Capillaries;
Dermis;
Glomus Tumor;
Humans;
Muscle, Smooth;
Muscles;
Skin
- From:Korean Journal of Dermatology
2012;50(11):969-973
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Glomus tumors are benign cutaneous neoplasm, occurring in the vascular hamartomatous tubercles of the glomus body, which is a myoarterial apparatus typically found in the reticular dermis of the skin. Histopathologically, glomus tumors are composed of neoplastic cells that resemble normal glomus cells, arranged around a varying number of thin-walled, sometimes branching capillaries. Immunohistochemically, neoplastic cells in glomus tumors clearly exhibit smooth muscle characteristics with expression of muscle-specific actin and alpha-smooth muscle actin; whereas, the expression of CD34 is rare. In this report, we present two cases of benign glomus tumors on the subungual area and palm. Tumor cells of glomus tumor in two patients were both positive for smooth muscle actin (SMA) and CD34 immunohistochemical staining. We thought that coexpression of SMA and CD34 adds support to the interpretation of these lesions as a family of perivascular neoplasms.
