Maternal Separation Does Not Produce a Significant Behavioral Change in Mice.
- Author:
Shawn TAN
1
;
Hin San HO
;
Anna Yoonsu SONG
;
Joey LOW
;
Hyunsoo Shawn JE
Author Information
- Publication Type:Brief Communication
- Keywords: Early-life stress; Maternal separation; Maternal separation with early weaning; Depression; Anxiety; Emotional memories
- MeSH: Animals; Anxiety; Cohort Studies; Depression; Genetic Predisposition to Disease; Humans; Male; Mice*; Models, Animal; Rats; Weaning
- From:Experimental Neurobiology 2017;26(6):390-398
- CountryRepublic of Korea
- Language:English
- Abstract: Early life adversities together with genetic predispositions have been associated with elevated risks of neuropsychiatric disorders during later life. In order to investigate the underlying mechanisms, many chronic, early-life stress paradigms in multiple animal models have been developed. Previously, studies reported that maternal separation (MS) in the early postnatal stages triggers depression-and/or anxiety-like behaviors in rats. However, similar studies using mice have reported inconsistent behavioral outcomes. In this study, we sought to assess behavioral outcomes from two different early-life stress paradigms; a conventional 3-hour MS and a maternal separation with early weaning (MSEW) paradigm using C57BL/6J male mice with independent cohorts. Our data demonstrated that both MS and MSEW paradigms did not produce reported behavioral anomalies. Therefore, MS paradigms in mice require further validation and modification.
