Deep Vein Thrombosis Casused by Congenital Absence of Inferior Vena Cava Combined with Hyperhomocysteinemia Due to C677T Methylenetetrahydrofolate Reductase Homozygos Mutation.
- Author:
Gi Young SUNG
1
;
Kee Hwan KIM
;
Ji Il KIM
;
Chang Hyeok AHN
;
Jeong Soo KIM
;
Sung Jin YU
;
Keun Woo LIM
;
Jong Man WON
;
Young Bok KOH
;
Seok Hyo CHANG
Author Information
1. Department of Surgery, College of Medicine, The Catholic University of Korea, cmckji@catholic.ac.kr
- Publication Type:Case Report
- Keywords:
Hyperhomocysteinemia;
DVT;
Agensis of inferior vena cava
- MeSH:
Adult;
Female;
Humans;
Hyperhomocysteinemia*;
Methylenetetrahydrofolate Reductase (NADPH2)*;
Prognosis;
Risk Factors;
Thrombophilia;
Vena Cava, Inferior*;
Venous Thrombosis*
- From:Journal of the Korean Society for Vascular Surgery
2003;19(2):202-206
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
We present a case of suprarenal & infrarenal absence of inferior vena cava combined with hyperhomocysteinemia in a 39-year-old woman who presented with symptoms of deep venous thrombosis. The patient has also C677T methylenetetrahydrofolate reductase homozygous mutation. Deep vein thrombosis has multifactorial etiology involving both genetic and acquired factors. Absence of inferior vena cava is a rare congenital anomaly, but recently it was confirmed as important risk factor for the development of deep vein thrombosis especially young person. Hypercoagulability by the hyperhomocysteinemia with suggested tendency to venous stasis mediated by agenesis of inferior vena cava must have caused the deep vein thrombosis in our patient. To our knowledge, such an association has not been reported. Clinical features and prognosis of this entity are discussed.
