Clinicopathological role of kidney injury molecule-1 in immunoglobulin A nephropathy.
10.1016/j.krcp.2014.07.004
- Author:
Yu Ho LEE
1
;
Yang Gyun KIM
;
Sang Ho LEE
;
Ju Young MOON
;
Kyung Hwan JEONG
;
Tae Won LEE
;
Chun Gyoo IHM
Author Information
1. Division of Nephrology, Department of Internal Medicine, Kyung Hee University School of Medicine, Seoul, Korea. cgihm@naver.com
- Publication Type:Original Article
- Keywords:
IgA nephropathy;
Kidney biomarkers;
Kidney injurymolecule-1(KIM-1)
- MeSH:
Acute Kidney Injury;
Follow-Up Studies;
Glomerulonephritis;
Glomerulonephritis, IGA*;
Humans;
Immunoglobulin A;
Inflammation;
Kidney*;
Male;
Prognosis
- From:Kidney Research and Clinical Practice
2014;33(3):139-143
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND: Urinary kidney injury molecule-1 (KIM-1) is an early and sensitive biomarker of acute kidney injury, but it is unclear if it is a biomarker of chronic glomerulonephritis. We evaluated whether urinary KIM-1 levels in patients with immunoglobulin A (IgA) nephropathy can be a marker to reflect clinicopathological severity and predict the prognosis. METHODS: We measured urinary KIM-1 levels in 40 patients (15 males; mean age 36.67+/-12.9 years) with IgA nephropathy and 10 healthy people (5 males; mean age 37.37+/-9.6 years) as controls. The correlation of urinary KIM-1 levels with patients' clinical parameters, histological grades, and follow-up data were analyzed using the modified H. S. Lee grading system and tubulointerstitial change scores. RESULTS: Urinary KIM-1 levels were higher in patients with IgA nephropathy than healthy controls (P=0.001). Univariate and multivariate regression analyses showed that urinary KIM-1 levels had a direct correlation with H. S. Lee grade and tubulointerstitial inflammation (P=0.004 and P=0.011, respectively). CONCLUSION: In patients with IgA nephropathy, urinary KIM-1 has a significant correlation with histopathologic severity.
