Changes of Serum Cytokines After the Long Term Immunotherapy with Japanese Hop Pollen Extracts.
10.3346/jkms.2006.21.5.805
- Author:
Young Min YE
1
;
Soo Keol LEE
;
Seung Hyun KIM
;
Dong Ho NAHM
;
Chang Hee SUH
;
Hae Sim PARK
Author Information
1. Department of Allergy and Rheumatology, Ajou University School of Medicine, Suwon, Korea. hspark@ajou.ac.kr
- Publication Type:Original Article ; Research Support, Non-U.S. Gov't
- Keywords:
Desensitization, Immunologic;
Allergen Immunotherapy;
Pollen;
Specific IgG;
Interleukin-10;
transforming growth factor beta 1
- MeSH:
Transforming Growth Factor beta/blood;
Receptors, IgE/blood;
Pollen/*immunology;
Poaceae/*immunology;
Interleukin-10/blood;
Immunoglobulin G/blood;
Immunoglobulin E/blood;
Humans;
*Desensitization, Immunologic;
Cytokines/*blood;
Bronchial Hyperreactivity/etiology
- From:Journal of Korean Medical Science
2006;21(5):805-810
- CountryRepublic of Korea
- Language:English
-
Abstract:
Japanese hop (Hop J) pollen has been considered as one of the major causative pollen allergens in the autumn season. We developed a new Hop J immunotherapy extract in collaboration with Allergopharma (Reinbeck, Germany) and investigated immunologic mechanisms during 3 yr immunotherapy. Twenty patients (13 asthma with rhinitis and 7 hay fever) were enrolled from Ajou University Hospital. Sera were collected before, 1 yr, and 3 yr after the immunotherapy. Changes of serum specific IgE, IgG1 , and IgG4 levels to Hop J pollen extracts and serum IL-10, IL-12, TGF-beta1 and soluble CD23 levels were monitored by ELISA. Skin reactivity and airway hyper-responsiveness to methacholine were improved during the study period. Specific IgG1 increased at 1 yr then decreased again at 3 yr, and specific IgG4 levels increased progressively (p<0.05, respectively), whereas total and specific IgE levels showed variable responses with no statistical significance. IL-10, TGF-beta1 and soluble CD23 level began to decrease during first year and then further decreased during next two years with statistical significances. (p<0.05, respectively). In con-clusion, these findings suggested the favorable effect of long term immunotherapy with Hop J pollen extracts can be explained by lowered IgE affinity and generation of specific IgG4 , which may be mediated by IL-10 and TGF-beta1.
