Cortical Laminar Necrosis associated with Osmotic Demyelination Syndrome.
- Author:
A Hyun CHO
1
;
Choong Gon CHOI
;
Sang Ahm LEE
Author Information
- Publication Type:Case Report
- Keywords: Cortical laminar necrosis; Hyponatremia; Osmotic demyelination syndrome
- MeSH: Adult; Aspartic Acid; Cerebral Cortex; Coma; Demyelinating Diseases*; Female; Humans; Hyponatremia; Lactic Acid; Magnetic Resonance Imaging; Necrosis*; Pons
- From:Journal of Clinical Neurology 2005;1(2):174-176
- CountryRepublic of Korea
- Language:English
- Abstract: Cortical laminar necrosis has been rarely observed in osmotic demyelination syndrome. We report a 32-year-old female patient who became comatose after the rapid correction of hyponatremia. There were high signal intensities in the pons and bilateral deep gray nuclei on T2-weighted MRI images, and linear hyperintensities along the cerebral cortices on T1-weighted images with a diffuse gyriform enhancement. MR spectroscopic findings showed a decrease of the N-acetyl aspartate peak and an increase in those of the lipid and lactate complex. The case demonstrates that a severe form of osmotic demyelination syndrome accompanying cortical laminar necrosis can result from the rapid correction of hyponatremia.
