Ziprasidone Induced Neutropenia.
- Author:
Jong Chul YANG
1
;
Seon Young KIM
;
Tae Won PARK
;
Yong Chul CHUNG
;
Sang Keun CHUNG
;
Ik Keun HWANG
Author Information
1. Department of Psychiatry, Chonbuk National University Medical School, Jeonju, Korea. jcyang@jnu.ac.kr
- Publication Type:Case Report
- Keywords:
Neutropenia;
Agranulocytosis;
Ziprasidone;
Antipsychotics
- MeSH:
Adult;
Agranulocytosis;
Antipsychotic Agents;
Citalopram;
Female;
Humans;
Incidence;
Korea;
Neutropenia*;
Neutrophils;
Quetiapine Fumarate
- From:Korean Journal of Psychopharmacology
2007;18(4):251-255
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Neutropenia and agranulocytosis are dangerous conditions seldom caused by antipsychotics. We report the case of a 35-year-old female patient who presented with neutropenia following ziprasidone administration. Ziprasidone was gradually increased to 160 mg/day in combination with escitalopram 10 mg/day. Following ziprasidone administration, her neutrophil count fell to 1700x10(3)/mm3, on day 45 and to 1500x10(3)/mm3 on day 57. Ziprasidone was immediately stopped, and quetiapine 25 mg was given from the next day onward, along with the escitalopram. Her neutrophil count rose to 2700x10(3)/mm3 2 days later, and was maintained at 2,900x10(3)/mm3 at 17 days after changing medication. To the best of our knowledge, this case represents the first report of ziprasidone - induced neutropenia in Korea. Further study is necessary to determine the incidence of neutropenia and its relationship with agranulocytosis secondary to ziprasidone.
