Effect of Airflow Limitation on Acute Exacerbations in Patients with Destroyed Lungs by Tuberculosis.
10.3346/jkms.2015.30.6.737
- Author:
Soo Jung KIM
1
,
2
;
Jinwoo LEE
;
Young Sik PARK
;
Chang Hoon LEE
;
Sang Min LEE
;
Jae Joon YIM
;
Young Whan KIM
;
Sung Koo HAN
;
Chul Gyu YOO
Author Information
1. Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Seoul National University Hospital
2. Seoul National University College of Medicine, Seoul, Korea. cgyoo@snu.ac.kr
- Publication Type:Original Article
- Keywords:
Acute Exacerbation;
Airflow Limitation;
Pulmonary Function;
Tuberculosis
- MeSH:
Comorbidity;
Female;
Forced Expiratory Volume;
Humans;
Lung Diseases, Obstructive/*diagnosis/*epidemiology;
Male;
Middle Aged;
Prevalence;
Republic of Korea/epidemiology;
Respiratory Function Tests/*statistics & numerical data;
Risk Factors;
Tuberculosis, Pulmonary/*diagnosis/*epidemiology
- From:Journal of Korean Medical Science
2015;30(6):737-742
- CountryRepublic of Korea
- Language:English
-
Abstract:
History of treatment for tuberculosis (TB) is a risk factor for obstructive lung disease. However, it has been unclear whether the clinical characteristics of patients with destroyed lung by TB differ according to the presence or absence of airflow limitation. The objective of the study was to evaluate differences in acute exacerbations and forced expiratory volume in 1 second (FEV1) decline in patients with destroyed lung by TB according to the presence or absence of airflow limitation. We performed a retrospective cohort study and enrolled patients with destroyed lung by TB. The presence of airflow limitation was defined as FEV1/forced vital capacity (FVC) < 0.7. One hundred and fifty-nine patients were enrolled, and 128 (80.5%) had airflow limitation. The proportion of patients who experienced acute exacerbation was higher in patients with airflow limitation compared to those without (89.1 vs. 67.7%, respectively; P = 0.009). The rate of acute exacerbation was higher in patients with airflow limitation (IRR, 1.19; 95% CI, 1.11-1.27). Low body mass index (X vs. X + 1; HR, 0.944; 95% CI, 0.895-0.996) in addition to airflow limitation (HR, 1.634; 95% CI, 1.012-2.638), was an independent risk factor for acute exacerbation. The annual decline of FEV1 was 2 mL in patients with airflow limitation and 36 mL in those without (P < 0.001). In conclusion, the presence of airflow limitation is an independent risk factor for acute exacerbation in patients with the destroyed lung by TB.
