Anticholinesterase and Anti-inflammatory Constituents from Beilschmiedia pulverulenta Kosterm.
10.20307/nps.2016.22.4.225
- Author:
Wan Mohd Nuzul Hakimi Wan SALLEH
1
;
Farediah AHMAD
;
Khong Heng YEN
;
Razauden Mohamed ZULKIFLI
Author Information
1. Department of Chemistry, Faculty of Science, University, Teknologi Malaysia (UTM), 81310 Skudai, Johor, Malaysia. farediah@kimia.fs.utm.my
- Publication Type:Original Article
- Keywords:
Anticholinesterase;
Anti-inflammatory;
Lignan;
Beilschmiedia pulverulenta
- MeSH:
Acetylcholine;
Cyclooxygenase 2;
Inhibitory Concentration 50;
Lignans
- From:Natural Product Sciences
2016;22(4):225-230
- CountryRepublic of Korea
- Language:English
-
Abstract:
Phytochemical investigation from the stem bark of Beilschmiedia pulverulenta resulted in the isolation of five lignans, (+)-yangambin (1), (+)-sesartemin (2), (+)-excelsin (3), (+)-sesamin (4), and (+)-syringaresinol (5), together with lupeol (6), lupenone (7), β-sitosterol (8), and β-sitostenone (9). Their structures were established by the analysis of their spectroscopic (1D and 2D NMR) and spectrometric (MS) data, as well as by comparison with those reported in the literature. The isolated lignans were tested for their anticholinesterase (AChE: acetylcholine esterase and BChE: butyryl cholineesterase) and anti-inflammatory (COX-2: cyclooxygenase-2 and LOX: lipoxygenase) activities. All the isolated lignans (1 – 5) exhibited significant inhibition activities in AChE/BChE and COX-2/LOX assays with IC50 values ranging from 168.8 – 504.2 µM and 21.0 – 59.4 µM, respectively.
