The Influence of Diabetes Mellitus on Short-Term Outcomes of Patients with Bleeding Peptic Ulcers.
10.3349/ymj.2012.53.4.701
- Author:
Atsuhiko MURATA
1
;
Shinya MATSUDA
;
Kazuaki KUWABARA
;
Yukako ICHIMIYA
;
Yoshihisa FUJINO
;
Tatsuhiko KUBO
Author Information
1. Department of Preventive Medicine and Community Health, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan. amurata@med.uoeh-u.ac.jp
- Publication Type:Original Article ; Research Support, Non-U.S. Gov't
- Keywords:
Bleeding peptic ulcers;
diabetes mellitus;
health care quality;
retrospective studies;
databases
- MeSH:
Aged;
Aged, 80 and over;
Diabetes Mellitus/*physiopathology;
Female;
Hemostasis, Endoscopic;
Hospital Mortality;
Humans;
Japan;
Length of Stay/statistics & numerical data;
Male;
Middle Aged;
Peptic Ulcer Hemorrhage/mortality/*pathology;
Regression Analysis
- From:Yonsei Medical Journal
2012;53(4):701-707
- CountryRepublic of Korea
- Language:English
-
Abstract:
PURPOSE: Little information is available on the influence of diabetes mellitus on the short-term clinical outcomes of patients with bleeding peptic ulcers. The aim of this study is to investigate whether diabetes mellitus influences the short-term clinical outcomes of patients with bleeding peptic ulcers using a Japanese national administrative database. MATERIALS AND METHODS: A total of 4863 patients treated by endoscopic hemostasis on admission for bleeding peptic ulcers were referred to 586 participating hospitals in Japan. We collected their data to compare the risk-adjusted length of stay (LOS) and in-hospital mortality of patients with and without diabetes mellitus within 30 days. Patients were divided into two groups: patients with diabetes mellitus (n=434) and patients without diabetes mellitus (n=4429). RESULTS: Mean LOS in patients with diabetes mellitus was significantly longer than those without diabetes mellitus (15.8 days vs. 12.5 days, p<0.001). Also, higher in-hospital mortality within 30 days was observed in patients with diabetes mellitus compared with those without diabetes mellitus (2.7% vs. 1.1%, p=0.004). Multiple linear regression analysis revealed that diabetes mellitus was significantly associated with an increase in risk-adjusted LOS. The standardized coefficient was 0.036 days (p=0.01). Furthermore, the analysis revealed that diabetes mellitus significantly increased the risk of in-hospital mortality within 30 days (odds ratio=2.285, 95% CI=1.161-4.497, p=0.017). CONCLUSION: This study demonstrated that presence of diabetes mellitus significantly influences the short-term clinical outcomes of patients with bleeding peptic ulcers.
