Lifestyle intervention might easily improve blood pressure in hypertensive men with the C genotype of angiotensin II type 2 receptor gene.
- Author:
Kaori KITAOKA
1
;
Azusa KITADE
;
Junko NAGAOKA
;
Kokoro TSUZAKI
;
Kiyomi HARADA
;
Wataru AOI
;
Sayori WADA
;
Hiroaki ASANO
;
Naoki SAKANE
;
Akane HIGASHI
Author Information
- Publication Type:Original Article
- Keywords: AT2R gene; blood pressure; salt excretion; lifestyle modification; hypertensive men
- MeSH: Alleles; Asian Continental Ancestry Group; Blood Pressure*; Cardiovascular Diseases; Cooking; Diet; Follow-Up Studies; Generalization (Psychology); Genotype*; Humans; Hypertension; Life Style*; Male; Polymerase Chain Reaction; Potassium; Receptor, Angiotensin, Type 2*; Resistance Training; Sample Size; Sodium; Walking
- From:Nutrition Research and Practice 2015;9(4):385-392
- CountryRepublic of Korea
- Language:English
- Abstract: BACKGROUND/OBJECTIVES: Recent studies have reported an association of the angiotensin II type 2 receptor (AT2R) 3123Cytosine/Adenine (3123C/A) polymorphism with essential hypertension and cardiovascular diseases. The purpose of the study was to investigate whether the AT2R 3123C/A polymorphism affects blood pressure for free-living hypertensive men during a 5-month intervention period. SUBJECTS/METHODS: The subjects were free-living hypertensive Japanese men aged 40 to 75 years who agreed to intervention in the period from 2004 to 2011. Detection of the AT2R 3123C/A polymorphism was determined by polymerase chain reaction. The dietary intervention was designed to decrease salt level and to increase potassium level through cooking instructions and self-monitoring of the diet. The exercise session consisted of activities such as stretching, resistance training, and walking. Blood pressure, urinary sodium and potassium excretion, dietary and lifestyle data, and non-fasting venous blood sample were collected at baseline and after the intervention period. RESULTS: Thirty nine subjects were eligible for participation and the follow-up rate was 97.4%. The C allele proportion was 57.9%. AT2R 3123C/A polymorphism was X-chromosome-linked, therefore we analyzed the C and A genotypes. At baseline, no significant differences were observed between the genotype groups. After the intervention, there were no significant differences in lifestyle habit between the groups. Nevertheless, the estimated salt excretion (g/day) was significantly decreased only in the C genotype (13.0-10.3, P = 0.031). No significant change was observed in systolic blood pressure (SBP) (mmHg) in the A genotype, but a significant decrease was observed in the C genotype (150.0-141.5, P = 0.024). CONCLUSTIONS: In the C genotype, it might be easy to improve SBP through lifestyle intervention in free-living hypertensive Japanese men, however generalization could not be achieved by the small sample size.
