An Experimental Study on Cerebral Paragonimiasis using Cats.
10.3348/jkrs.1994.30.6.1003
- Author:
Yoon KONG
;
Seung Yull CHO
;
Moon Hee HAN
;
Jin Mo GOO
;
In Kyu YU
;
Yong Moon SHIN
;
Seon Kyu LEE
;
Kee Hyun CHANG
;
Sung Wook CHO
- Publication Type:Original Article
- MeSH:
Adult;
Animals;
Autopsy;
Brain;
Cats*;
Diagnosis;
Drug Therapy;
Humans;
Inflammation;
Lung;
Metacercariae;
Paragonimiasis*;
Paragonimus;
Radiography, Thoracic;
Skull;
Trephining
- From:Journal of the Korean Radiological Society
1994;30(6):1003-1012
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: It is important to diagnose paragonimiasis in early active stage because it can be dured by chemotherapy. However, it is difficult to make a correct diagnosis of cerebral paragonimiasis in the early active stage, and the radiographic findings of cerebral paragonimiasis have been rarely reported. Thus, this experimental study was designed to produce early active cerebral paragonimiasis and to demonstrate radiologic-pathologic correlations. MATERIALS AND METHODS: In 8 cats, 7-8 metacercariae of Paragonimus westerrnani were directly introduced into the brain parenchyma of each cat's after trephination of the skull. In anogher 16 cats, the juvenile worms and the adult worms that had developed for varying periods (2 weeks, 4 weeks, 6 weeks, 8 weeks and 12 weeks) in the lunges of another cats were introduced into the brain parenchyma of each cat's with the same procedures described above. Follw-up MR images and chest radiographs were obtained at 2 days, 1 weeks, 2 weeks, 4 weeks and 8 weeks after innoculation. The autopsies and histopathological examinations of the cat's brain were undertaken in 22 cats. In 9 cats that were suspected with pulmonary lesions on chest radiograph, the soft tissue radiographs of inflated-fixed lungs were obtained. RESULTS: In one cat with innoculation of adult worm, acute suppurative inflammation of the brain parenchyma was demonstrated. But the other cats with innoculction of adult worm or juvenile worm and the cats with innoulation of metacercaris did not reveal any evidence of acute cerebral paragonimiasis. More than half of the introduced metacercariae(5 out of 8 cats) were found in the lung parenchyma, while only 25%(4 out of 16 cats) of the adult worm innoculated cats were. CONCLUSION: Acute suppurative inflammation suggesting acute stage cerebral paragonimiasis was obtained in one case of adult worm innoculated cat. Most of the innoculated metacercariae and some of the juvenile worms or adult worms were migrated to the lungs.
