Investigation of Sarcopenia and Its Association with Cardiometabolic Risk Factors in Elderly Subjects.
10.4235/jkgs.2010.14.3.121
- Author:
Jung Hee KIM
1
;
Yul HWANG BO
;
Eun Shil HONG
;
Jung Hun OHN
;
Chi Hoon KIM
;
Hye Won KIM
;
Hwa Young AHN
;
Ji Won YOON
;
Seon Mee KANG
;
Young Joo PARK
;
Hak Chul JANG
;
Soo LIM
Author Information
1. Department of Internal Medicine, Seoul National University of College of Medicine, Seoul, Korea. limsoo@snu.ac.kr
- Publication Type:Original Article
- Keywords:
Sarcopenia;
Cardiometabolic risk factors;
Elderly
- MeSH:
Absorptiometry, Photon;
Adiponectin;
Aged;
Body Mass Index;
Cholesterol;
Cholesterol, HDL;
Cholesterol, LDL;
Cohort Studies;
Fasting;
Female;
Glucose;
Humans;
Insulin Resistance;
Korea;
Male;
Muscle, Skeletal;
Plasma;
Prevalence;
Risk Factors;
Sarcopenia;
Triglycerides;
Young Adult
- From:Journal of the Korean Geriatrics Society
2010;14(3):121-130
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: The aim of this study was to investigate sarcopenia and its association with cardiometabolic risk factors in a community-based elderly cohort in Korea. METHODS: We recruited 287 men and 278 women aged 65 years or older and without physical disability. Appendicular skeletal muscle mass (ASM) was measured with dual energy X-ray absorptiometry. We used two definitions for sarcopenia-ASM divided by height2 (kg/m2) or by weight (%) <1 SD below the sex-specific mean for young adults. We compared RBP-4, adiponectin, hsCRP, lipid profiles, and insulin resistance between the sarcopenic and normal groups using ASM/Ht2 and ASM/Wt. RESULTS: The prevalence of sarcopenia was 35.3% in men and 13.4% in women with sarcopenia defined by ASM/Ht2. However, it was 38.3% in men and 62.6% in women by ASM/Wt. In correlation analysis, body mass index was positively correlated with ASM/Ht2 and negatively correlated with ASM/Wt. The sarcopenic group, when defined as ASM/Ht2, showed lower RBP4, fasting plasma glucose, and HOMA-IR and higher adiponectin than the normal group but not significantly different lipid profiles. The sarcopenic group defined by ASM/Wt had higher RBP4, fasting plasma glucose, and HOMA-IR, and lower adiponectin than the normal group in both sexes. Only in the males did the sarcopenic group defined by ASM/Wt reveal higher total cholesterol, triglycerides, and LDL cholesterol, and lower HDL cholesterol than the normal group. CONCLUSION: In conclusion, the sarcopenic group defined by ASM/Wt was more closely associated with cardiometabolic risk factors than the normal group in a community-based elderly cohort.
