The effect-site concentration of remifentanil for blunting hemodynamic responses: comparative study in single-lumen endotracheal and double-lumen endobronchial intubation.
10.17085/apm.2017.12.3.247
- Author:
Sun Kyung PARK
1
;
Hyun Jung KIM
Author Information
1. Department of Anesthesiology and Pain Medicine, Jeju National University School of Medicine, Jeju, Korea. hjanesthesia@empas.com
- Publication Type:Comparative Study ; Original Article
- Keywords:
Endotracheal anesthesia;
Intubation;
Remifentanil
- MeSH:
Anesthesia;
Anesthesia, Endotracheal;
Anesthesia, General;
Anesthesia, Intravenous;
Hemodynamics*;
Humans;
Intubation*;
Intubation, Intratracheal;
Methods;
Propofol
- From:Anesthesia and Pain Medicine
2017;12(3):247-250
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: This study undertook to compare the effect-site concentration of remifentanil for prevention of hemodynamic responses to endotracheal intubation, employing the single-lumen tracheal tube and the double-lumen bronchial tube during total intravenous anesthesia. METHODS: Based on the nature of the surgery, 38 patients undergoing general anesthesia were assigned either to the single-lumen tube group or the double-lumen tube group. Anesthesia was induced by a target controlled infusion of propofol, with an effect-site concentration of 4 µg/ml. Remifentanil was then administered to the first patient in each group, with an effect-site concentration of 3.5 ng/ml. Subsequent concentration of remifentanil was determined by hemodynamic responses of the previous patient to intubation, based on the up-and-down method. RESULTS: The effect-site concentrations of remifentanil for prevention of hemodynamic responses to endotracheal intubation in 50% of patients (EC₅₀) were 2.8 ng/ml (95% CI, 2.0–3.7 ng/ml) in the single-lumen tube group, and 2.9 ng/ml (95% CI, 2.5–3.2 ng/ml) in the double-lumen tube group. No significant difference was observed between the two groups. CONCLUSIONS: The effect-site concentration of remifentanil for prevention of hemodynamic responses to endotracheal intubation did not differ during total intravenous anesthesia, using either the single-lumen tracheal tube or the double-lumen bronchial tube.
