A Case of Rheumatoid Arthritis Associated with Renal Amyloidosis and Crescentic Glomerulonephritis.
- Author:
Jung Hyeon CHOI
1
;
Byeong Kuk IM
;
Jun Hyeock CHOI
;
Hyeon Kyeong CHO
;
Youn Gil CHOI
;
Heung Soo KIM
;
Gyu Tae SHIN
;
Do Hun KIM
;
Jae Hoo HAN
Author Information
1. Department of Internal Medicine, College of Medicine, Ajou University, Suwon, Korea.
- Publication Type:Original Article
- Keywords:
Amyloidosis;
Crescentic Glomerulonephritis;
Rheumatoid arthritis
- MeSH:
Adrenal Cortex Hormones;
Amyloidosis*;
Arthritis, Rheumatoid*;
Biopsy;
Creatinine;
Cyclophosphamide;
Female;
Glomerulonephritis*;
Humans;
Kidney;
Methylprednisolone;
Middle Aged;
Nephrotic Syndrome;
Plaque, Amyloid;
Proteinuria
- From:Korean Journal of Nephrology
2001;20(6):1058-1063
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
A case of renal amyloidosis with crescentic glomerulonephritis associated with rheumatoid arthritis is described. A 60-year-old female with 15 years' history of rheumatoid arthritis developed nephrotic syndrome followed by rapid deterioration of renal function. Glomerular amyloid deposition and sclerotic change was present in kidney biopsy specimen and crescentic change was found in 85% of the glomerulus. Electron microscopic finding of glomerulus showed randomly oriented, rigid-appearing, long nonbranching fibrils. The patient was treated with intravenous high-dose methylprednisolone pulses combined with intravenous cyclophosphamide followed by oral corticosteroids. Three months after the above treatment, renal function gradually improved, reaching serum creatinine level to 2.5 mg/dL. But the nephrotic range proteinuria persisted.
