Two Cases of Gitelman's Syndrome Diagnosed by Renal Clearance Study.
- Author:
Ju Young KI
1
;
Hye Young KIM
;
Jung Muk IM
;
Kwang Sik OH
;
Young Sun PARK
;
Sun Gil KWON
;
Jung Sung SHIN
;
Mi Sung KIM
;
Jung Hun JI
;
Jae Ho EARM
Author Information
1. Department of Internal Medicine, College of Medicine, Chungbuk National University, Cheongju, Korea.
- Publication Type:Case Report
- Keywords:
Gitelman's syndrome;
Renal clearance study;
Water loading;
Furosemide;
Thiazide
- MeSH:
Alkalosis;
Calcium;
Filtration;
Furosemide;
Gitelman Syndrome*;
Humans;
Loop of Henle;
Magnesium Chloride;
Plasma;
Renin;
Sodium;
Water
- From:Korean Journal of Nephrology
2001;20(6):1064-1069
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
We have experienced two patients who had hypokalemic metabolic alkalosis as well as hypomagnesemia and hypocalciuria with elevated plasma renin activity. We have performed renal clearance study after water loading, administration of furosemide and thiazide in two patients and two normal controls. Maximal free water clearance per 100 mL glomerular filtration rate(CH2O) and distal fractional chloride reabsorption[CH2O/(CH2O+CCl)] in our patients were reduced than the controls. Chloride clearance(CCl) was increased after furosemide administration but not after thiazide administration. Distal fractional chloride reabsorption[CH2O/(CH2O+CCl)] was dramatically decreased by furosemide administration in our patients, whereas thiazide had little effect on it. Fractional excretion of sodium, chloride, magnesium, calcium was increased by furosemide administration, whereas thiazide administration had little effect on this parameters. These findings suggested the presence of a defect in the distal convoluted tubule rather than in the thick ascending loop of Henle. Herein, we report two cases of Gitelman's syndrome diagnosed by renal clearace study after water loading, administration of furosemide and thiazide.
