A case of primary pulmonary NK-cell lymphoma.
- Author:
Jung Hun LEE
1
;
Jooryung HUH
;
Sang We KIM
;
Ok Bae KO
;
Sun Man YOUN
;
Yoon Koo KANG
;
Cheolwon SUH
Author Information
1. Department of Internal Medicine, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea. csuh@amc.seoul.kr
- Publication Type:Case Report
- Keywords:
NK-cell lymphoma;
Primary pulmonary
- MeSH:
Cough;
Cytoplasm;
Drug Therapy;
Gene Rearrangement, T-Lymphocyte;
Herpesvirus 4, Human;
Humans;
Korea;
Lung;
Lymphoma*;
Middle Aged;
Receptors, Antigen, T-Cell;
Thoracoscopy;
Thorax;
Tomography, X-Ray Computed
- From:Korean Journal of Medicine
2005;68(2):215-219
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
NK-cell lymphoma, distinct clinicopathologic entity, almost always occurs in the naso-sinal region. NK-cell lymphomas of other extranodal sites have also been recognized in previous case reports, but very rare. As far as we know, only four cases of primary pulmonary NK-cell lymphoma were reported worldwide. We experienced a case of primary pulmonary NK-cell lymphoma. A 54-year-old man was admitted because of cough and chest discomfort. The chest CT shows multifocal ground-glass and nodular opacities in both lungs. Video Assisted Thoracoscopy (VATS) was performed to assess the lung lesion. The tumor cells were characterized by cytoplasmic CD3 (+), CD56 (+), T-cell receptor antigen (-), Epstein-Barr Virus (+) and T-cell gene rearrangement (-), These findings were compatible with NK-cell lymphoma. So we performed the whole body Flurodeoxyglucose-Positron Emission Tomography (FDG-PET) to exclude any other lesion. The FDG-PET showed multiple hypermetabolic lesions only located in both lungs. The patient underwent 6 cycles of chemotherapy according to a CHOP regimen. Now his disease state is complete remission. To our knowledge, this is the first case of primary pulmonary NK-cell lymphoma in Korea.
