Effect of Surgical Therapy on the Courses of Human Papillomavirus Infection in Cervical Intraepithelial Neoplasia.
- Author:
Jin Lae ROH
1
;
Jae Wook KIM
;
Young Tae KIM
;
Sung Hoon KIM
;
Kun Hong KIM
Author Information
1. Department of Obstetrics and Gynecology, Yonsei University College of Medicine, Seoul, Korea.
- Publication Type:Original Article
- Keywords:
Human papillomavirus (HPV);
Cervical intraepithelial neoplasia (CIN);
HPV DNA genotyping;
Surgical therapy
- MeSH:
Cervical Intraepithelial Neoplasia*;
DNA;
Humans*;
Hysterectomy;
Oligonucleotide Array Sequence Analysis;
Papillomavirus Infections*;
Prospective Studies;
Seoul
- From:Korean Journal of Obstetrics and Gynecology
2004;47(3):451-457
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
OBJECTIVE: To investigate whether human papillomavirus (HPV) associated with cervical intraepithelial neoplasia was successfully eliminated after surgical therapy such as large loop excision of transformation zone (LLETZ) or type I extended hysterectomy. METHODS: Seventy four cervical intraepithelial neoplasia (CIN) patients with HPV infection who were admitted for LLETZ or type I extended hysterectomy were recruited into this prospective study. HPV infection was confirmed by HPV DNA genotyping using HPV DNA Chip (Biomedlab, Seoul, Korea) before and after surgical therapy. RESULTS: According to the assay used (HPV DNA Chip(R)) at the postoperative visit, 82.5% of treated patients were completely free from HPV infection. And there was no statistical difference between LLETZ and type I extended hysterectomy (p=0.452). However, there was persistent infection in 17.5% of treated patients after final surgical therapy. CONCLUSION: Although the HPV infection associated with CIN was effectively eliminated after LLETZ and type I extended hysterectomy, there was persistent infection in 17.5% of treated patients. Therefore, the careful followed-up examination of HPV infection should be taken in these patients.
