Protective effects of a mineral aqueous solution on toxicity in mouse liver and kidney.
- Author:
In Jae PARK
1
;
Se Yeoun CHA
;
Min KANG
;
Yang Sub SO
;
Ji Yun BAHNG
;
Hyung Kwan JANG
Author Information
1. Department of Veterinary Infectious Diseases and Avian Diseases, College of Veterinary Medicine & Korea Zoonosis Research Institute, Chonbuk National University, Jeonju 561-756, Korea. hkjang@chonbuk.ac.kr
- Publication Type:Original Article
- Keywords:
CCl4-induced acute liver failure;
cisplatin-induced acute renal failure;
mineral aqueous solution;
silicon
- MeSH:
Acute Kidney Injury;
Alanine Transaminase;
Animals;
Aspartate Aminotransferases;
Blood Urea Nitrogen;
Contracts;
Creatine;
Cytokines;
Interleukin-6;
Kidney*;
Liver Failure, Acute;
Liver*;
Mice*;
Mortality;
Silicon;
Tumor Necrosis Factor-alpha
- From:Korean Journal of Veterinary Research
2013;53(3):169-174
- CountryRepublic of Korea
- Language:English
-
Abstract:
We demonstrated that a mineral aqueous solution (MAS) administered to mice functionally and histologically protected against cisplatin-induced acute renal failure (ARF) and CCl4-induced acute liver failure (ALF). In ARF model, 0.4 and 0.2% MAS decreased mortality and the serum concentrations of blood urea nitrogen (BUN) and creatine in mice. Additionally, 0.4 and 0.2% MAS reduced contraction of distal convoluted tubules and suppressed expression of the proinflammatory cytokines interlukein-6 (IL-6) and tumor necrosis factor (TNF-alpha) in the kidney. In ALF model, 0.4 and 0.2% MAS decreased serum concentrations of alanine aminotransferase and aspartate aminotransferase in mice. Additionally, 0.4 and 0.2% MAS reduced necrotic areas and suppressed expression of IL-6 and TNF-alpha in the liver. These results indicate that a MAS might have protective effects against ARF and ALF.
