Clinical trial of diltiazem on dystrophic calcinosis cutis in a dog.
- Author:
Na Young CHO
1
;
Dae Hee CHO
;
Ho Jung CHOI
;
Seong Mok JEONG
;
Young Won LEE
;
Seong Jun PARK
Author Information
1. College of Veterinary Medicine, Research Institute of Veterinary Medicine, Chungnam National University, Daejeon 305-764, Korea. parksj@cnu.ac.kr
- Publication Type:Clinical Trial ; Case Report
- Keywords:
diltiazem;
dog;
dystrophic calcinosis cutis;
hyperadrenocorticism
- MeSH:
Adrenocortical Hyperfunction;
Alanine Transaminase;
Alkaline Phosphatase;
Animals;
Basophils;
Calcinosis*;
Calcium;
Child;
Cholesterol;
Dermis;
Diltiazem*;
Dogs*;
Female;
gamma-Glutamyltransferase;
Hepatomegaly;
Humans
- From:Korean Journal of Veterinary Research
2013;53(3):181-184
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Dystrophic calcinosis cutis associated with spontaneous hyperadrenocorticism was diagnosed in a 8-year-old female Chihuahua dog with erythematous, erosive, numerous papules, plaques, and crusts on the bilateral trunk, and inguinal region. Serum biochemical abnormalities included increases in alkaline phosphatase (ALP), alanine aminotransferase (ALT), gamma-glutamyl transpeptidase (GGT), and cholesterol. Radiographs showed mild hepatomegaly and subcutaneous lobulated calcific deposits. Histopathologic examination demonstrated diffuse deposition of basophilic calcified material in the dermis. Von Kossa's stain confirmed calcium deposition. Therapy with diltiazem was useful in resolving calcinosis.
