Loss of Caveolin 1 is Associated With the Expression of Aquaporin 1 and Bladder Dysfunction in Mice.
- Author:
Seheon JUNG
1
;
Sun Ouck KIM
;
Kyung Aa CHO
;
Seung Hee SONG
;
Teak Won KANG
;
Kwangsung PARK
;
Dongdeuk KWON
Author Information
- Publication Type:Original Article
- Keywords: Aquaporin 1; Caveolin 1; Bladder
- MeSH: Animals; Aquaporin 1*; Arterioles; Blotting, Western; Capillaries; Caveolin 1*; Fluorescent Antibody Technique; Mice*; Mice, Knockout; Urinary Bladder*; Urothelium; Venules
- From:International Neurourology Journal 2015;19(1):34-38
- CountryRepublic of Korea
- Language:English
- Abstract: PURPOSE: It is suggested that caveolin and aquaporin might be closely associated with bladder signal activity. We investigated the effect of the deletion of caveolin 1, using caveolin 1 knockout mice, on the expression of aquaporin 1 in order to identify their relation in the urothelium of the urinary bladder. METHODS: The cellular localization and expressions of aquaporin 1 and caveolin 1, in the wild type and caveolin 1 knockout mice urinary bladder, were examined by Western blot and immunofluorescence techniques. RESULTS: Aquaporin 1 and caveolin 1 were coexpressed in the arterioles, venules, and capillaries of the suburothelial layer in the wild type controls. Aquaporin 1 protein expression was significantly higher in the caveolin 1 knockout mice than in the wild type controls (P <0.05). CONCLUSIONS: The results imply that aquaporin 1 and caveolin 1 may share a distinct relation with the bladder signal activity. This might play a specific role in bladder dysfunction.
