Successful pregnancy and birth in a patient with panhypopituitarism caused by craniopharyngioma.
- Author:
Yun Hee KOO
1
;
Chung Hoon KIM
;
Soo Jeong LEE
;
Hyang Ah LEE
;
Sa Ra LEE
;
Sung Hoon KIM
;
Hee Dong CHAE
;
Byung Moon KANG
Author Information
1. Department of Obstetrics and Gynecology, College of Medicine, University of Ulsan, Asan Medical Center, Seoul, Korea. chkim@amc.seoul.kr
- Publication Type:Case Report
- Keywords:
Panhypopituitarism;
Craniopharyngioma;
Ovulation induction;
Pregnancy
- MeSH:
Adult;
Chorionic Gonadotropin;
Craniopharyngioma*;
Deamino Arginine Vasopressin;
Diabetes Insipidus;
Estrogens;
Female;
Fertilization;
Gonadotropins;
Hormone Replacement Therapy;
Humans;
Hypogonadism;
Insemination;
Medroxyprogesterone Acetate;
Ovulation;
Ovulation Induction;
Parturition*;
Prednisolone;
Pregnancy*
- From:Korean Journal of Obstetrics and Gynecology
2005;48(10):2462-2467
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Conceptions and uncomplicated pregnancies in patients with panhypopituitarism are rare especially after treatment of craniopharyngioma. We recently experienced a case of a patient with panhypopituitarism who became pregnant by gonadotropin therapy and gave birth to a healthy baby. A 33-year-old woman developed hypogonadotropic hypogonadism and diabetes insipidus because of craniopharyngioma which was surgically removed. Post-operative panhypopituitarism with diabetes insipidus was treated with adequate doses of L-thyroxin, prednisolone, desmopressin, medroxyprogesterone acetate (MPA), conjugated estrogen. To induce ovulation, human menopausal gonadotropin (hMG) and human chorionic gonadotropin (hCG) were administered, and a single intrauterine insemination (IUI) procedure was performed. The patient became pregnant and gave birth to a healthy baby. This case suggests that ovulation induction using gonadotropins and comprehensive hormone replacement therapy can result in the successful pregnancy in patients with panhypopituitarism after treatment of craniopharyngioma.
