A Case of Propylthiouracil Induced Diffuse Pulmonary Hemorrhage.
- Author:
Sung Yong LEE
1
;
Jin Yong JUNG
;
Kyoung Ju LEE
;
Seung Hyeun LEE
;
Se Joong KIM
;
Eun Joo LEE
;
Gyu Young HUR
;
Hae Chul JUNG
;
Sang Yeub LEE
;
Je Hyeong KIM
;
Chol SHIN
;
Jae Jeong SHIM
;
Kwang Ho IN
;
Kyung Ho KANG
;
Se Hwa YOO
Author Information
- Publication Type:Case Report
- Keywords: Propylthiouracil; ANCA; Diffuse alveolar hemorrhage
- MeSH: Antibodies, Antineutrophil Cytoplasmic; Cytoplasm; Diagnosis; Hemorrhage*; Humans; Korea; Macrophages; Propylthiouracil*; Vasculitis
- From:Tuberculosis and Respiratory Diseases 2005;58(1):78-82
- CountryRepublic of Korea
- Language:Korean
- Abstract: Propylthiouracil(PUT) is a drug which used at Grave's disease. But PTU has recently been observed to associated with antineutrophil cytoplasmic antibody(ANCA)-positive vasculitis resulting in, infrequently, diffuse alveolar he?morrhage. We report the case of a patient who developed diffuse pulmonary hemorrhage after she had been taking PTU for two years. She had received a diagnosis of Grave's disease at two years ago. The serologic study was positive for ANCA with myeloperoxidase(MPO) specificity. Bronchoalveloar lavage(BAL) fluid analysis revealed hemosiderin- laden macrophages. Such findings suggested propylthiouracil?induced dffuse pulmonary hemorrhage associated with antineutrophil cytoplasmic antibody. To our knowledge, this represents the first documentation in a case of PTU-induced diffuse pulmonary hemorrhage in Korea.
