Clinical Characteristics and Prognostic Factors of Papillary Microcarcinoma: Results from Retrospective Analysis of 176 Patients.
10.16956/kjes.2009.9.2.79
- Author:
Dae Keun SONG
1
;
Young Jin CHOI
;
Yoon Jung KANG
;
Hye Won PARK
;
Joo Seung PARK
;
Byung Sun JOE
;
Chang Nam KIM
;
Min Koo LEE
Author Information
1. Department of Surgery, Eulji Medical Center, Eulji University School of Medicine, Daejeon, Korea. yjchoi@eulji.ac.kr
- Publication Type:Original Article
- Keywords:
Papillary thyroid microcarcinoma;
Lymph node metastasis;
Capsular invasion
- MeSH:
Female;
Humans;
Lymph Nodes;
Male;
Medical Records;
Neoplasm Metastasis;
Retrospective Studies*;
Thyroid Gland;
Thyroidectomy
- From:Korean Journal of Endocrine Surgery
2009;9(2):79-84
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: The clinical importance and characteristics of papillary thyroid microcarcinoma (PTC) are still under debate, and the criteria for appropriate treatment have yet to be established. In this study, we attempted to examine the appropriate extent of surgery and the desirability of prophylactic lymph node (LN) dissection through identification of factors influencing LN metastasis and capsular invasions. METHODS: We reviewed the medical records of 176 consecutive biopsy-proven PTC patients. The clinical and pathological prognostic factors including LN metastasis and capsular invasion were analyzed. Chi-square test and independent sample T-test were used for statistical analysis. RESULTS: The median age of patients was 47-years-of-age (range 23~80 years). Among 108 patients who underwent central LN dissection, 38 (35.8%) patients showed LN metastasis. Univariate analysis revealed that male patients showed significantly more LN metastasis than female patients and lymphovascular invasion significantly affected LN metastasis. Twenty-eight (14.8%) patients showed capsular invasion. Tumor size, especially tumors ≥5 mm in diameter, and tumor multiplicity were significantly associated with capsular Invasion. Lymphatic or venous invasion also affected the occurrence of capsular invasion. CONCLUSION: Patients who are male, have a tumor larger than 5 mm in diameter, or multiple tumors are more likely to develop LN metastasis or capsular invasions. These factors could help us to decide the extent of thyroidectomy and to select patients who need prophylactic LN dissection.
