Molecular characterizations of phosphoprotein of rabies virus circulating in Korea.
- Author:
Ha Hyun KIM
1
;
Dong Kun YANG
;
Jeong Kuk JEON
;
Soo Dong CHO
;
Jae Young SONG
Author Information
1. Animal, Plant and Fisheries Quarantine and Inspection Agency, Anyang 430-757, Korea. yangdk@korea.kr
- Publication Type:Original Article
- Keywords:
molecular epidemiology;
P gene;
rabies virus
- MeSH:
Amino Acid Substitution;
Animals;
Consensus Sequence;
Dogs;
Genotype;
Glycoproteins;
Humans;
Korea;
Lyssavirus;
Molecular Epidemiology;
Nucleocapsid Proteins;
Rabies;
Rabies virus;
Republic of Korea
- From:Korean Journal of Veterinary Research
2012;52(1):9-18
- CountryRepublic of Korea
- Language:English
-
Abstract:
Rabies is a major zoonotic disease that causes approximately 55,000 human deaths worldwide on an annual basis. The nucleocapsid protein and glycoprotein genes of the Korean rabies virus (RABV) have been subjected to molecular and phylogenetic analyses. Although the phosphoprotein (P) has several important functions in viral infection and pathogenicity, the genetic characterizations of the P of Korean RABV isolates have not yet been established. In the present study, we conducted genetic analyses of P genes of 24 RABV isolates circulating in the Republic of Korea (hereafter, Korea) from 2008 to 2011. This study revealed that the P genes of Korean RABVs are genetically similar to those of RABV strains of lyssavirus genotype I including V739 (dogs, Korea), NNV-RAB-H (humans, India), NeiMeng925 (raccoon dogs, China), and RU9.RD (raccoon dogs, Russia). Among Korean isolates, the RABV P genes showed low variability in the variable domains among Korean isolates; they had specific consensus sequences and amino acid substitutions capable of identifying geographic characteristics and retained specific sequences thought to be important for viral function. These results provide important genetic characteristics and epidemiological information pertaining to the P gene of the Korean RABV.
