Studies on the anti-parasitic efficacy and safety of ivermectin and pyrantel pamoate compound against Dirofilaria immitis in dogs.
- Author:
Heejeong YOUN
1
;
Jeong Chan RA
;
Byung Ki KIM
;
Yong Suk LIM
;
Kyong Hee KIM
;
Kyong Eun LEE
Author Information
1. College of Veterinary Medicine, Seoul National University, Seoul 151-742, Korea. younhj@snu.ac.kr
- Publication Type:Original Article
- Keywords:
Dirofilaria immitis;
ivermectin;
ivermectin and pyrantel pamoate compound;
pyrantel pamoate
- MeSH:
Animals;
Dirofilaria;
Dirofilaria immitis;
Dogs;
Heart Ventricles;
Ivermectin;
Parasites;
Pulmonary Artery;
Pyrantel;
Pyrantel Pamoate
- From:Korean Journal of Veterinary Research
2012;52(1):53-56
- CountryRepublic of Korea
- Language:English
-
Abstract:
Dirofilaria (D.) immitis is an important canine parasitic nematode in dogs. D. immitis parasitizes the right ventricle and pulmonary artery of dogs. An ivermectin and pyrantel pamoate compound (IPPC) was administered to dogs naturally infected with this parasite. IPPC is composed of 68.0, 136.0 and 272.0 microg of ivermectin and 57.0, 114.0 and 227.0 mg pyrantel pamoate for small, middle, and large animals. Ivermectin has activity against nematodes and ectoparasites in dogs. Pyrantel pamoate is also effective against nematodes in dogs. Our results showed that this drug combination has good efficacy in D. immitis infected dogs.
