Filtration Effects of Leukocyte Removal Filter for Platelet Concentrates.
- Author:
Hyun Sook CHI
;
Seog Woon KWON
;
Won Il OH
;
Mi Kyung LEE
;
Hyun Jun PARK
;
Tae Jin HAN
;
Bum Ryoul CHOI
;
Tae Hee MIN
- Publication Type:Original Article
- MeSH:
Blood Platelets*;
Cytokines;
Dihydroergotamine;
Filtration*;
Humans;
Interleukin-1beta;
Interleukin-8;
Leukocytes*;
Tissue Donors;
Tumor Necrosis Factor-alpha
- From:Korean Journal of Blood Transfusion
1996;7(2):241-245
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Some variables can influence the efficiency of leukocyte removal filter for red cell concentrates. We performed this study to evaluate whether the filtration efficiency for platelet concentrates(PCs) can be influenced by bedside filter(PXL8K, Pall Corporation, USA) used, platelet storage time and transient stopping of platelet agitation, and to measure the amount of cytokines released from donor leukocytes in PCs during the storage time. In addition, we examined the effect of leukocyte reduction by filtration before the storage of PCs on the subsequent generation of cytokines. Any of the above mentioned variables did not make significant differences. From day 1 to day 5, there were significant increases in IL-1 beta (<1 vs. 8.6 pg/mL, p<0.05), IL-8 (<10 vs. 455.3 pg/mL, p<0.05) and TNF-alpha (<4 vs. 16.6 pg/mL, p<0.05) in unflltered PCs, whereas no increased revels of cytokines were found in the cases of prestorage filtration.
