Myopathy With Anti Signal Recognition Particle Antibody.
- Author:
Hyun Jung HONG
1
;
Il Nam SUNWOO
;
Ha Young SHIN
;
Se Hoon KIM
;
Jeong Hee CHO
;
Seung Min KIM
Author Information
1. Department of Neurology, Pathology, Yonsei University College of Medicine, Seoul, Korea. kimsm@yuhs.ac
- Publication Type:Case Report
- Keywords:
Idiopathic inflammatory myopathies;
Autoantibodies;
Signal recognition particle
- MeSH:
Antibodies;
Autoantibodies;
Biopsy;
Deglutition Disorders;
Dysarthria;
Humans;
Inflammation;
Middle Aged;
Muscle Weakness;
Muscles;
Muscular Diseases;
Myositis;
Polymyositis;
Signal Recognition Particle
- From:Journal of the Korean Neurological Association
2011;29(3):231-233
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Myopathies associated with anti-signal-recognition particle (SRP) antibodies usually present with severe muscle weakness and exhibit necrotizing myopathy with little inflammation pathologically. Here we report a case of a 61-year-old man who presented with subacute progressive proximal muscle weakness, dysarthria, and dysphagia. Although polymyositis was expected clinically, muscle biopsy revealed myopathic changes with degenerating fibers without definite inflammation. Further laboratory study revealed that the patient was positive for anti-SRP antibodies.
