Cerebrovascular Reserve Measured by Acetazolamide-challenged Tc-99m ECD Brain Perfusion SPECT in Symptomatic Internal Carotid Artery and Middle Cerebral Artery Disease.
- Author:
Eun Hee KIM
1
;
Yang Ha HWANG
;
Byung Chul AHN
;
Doo Kyo JUNG
;
Chung Kyu SUH
;
Sung Pa PARK
Author Information
1. Department of Neurology, School of Medicine, Kyungpook National University, Korea. sppark@knu.ac.kr
- Publication Type:Original Article
- Keywords:
Cerebral infarction;
Middle cerebral artery;
Internal carotid artery;
SPECT
- MeSH:
Acetazolamide;
Brain*;
Carotid Artery, Internal*;
Cerebral Infarction;
Constriction, Pathologic;
Hemodynamics;
Humans;
Incidence;
Middle Cerebral Artery*;
Perfusion*;
Stroke;
Tomography, Emission-Computed, Single-Photon*
- From:Journal of the Korean Neurological Association
2003;21(5):468-472
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: Hemodynamic evaluation of the brain may be helpful for the identification of a risk of stroke in patients with middle cerebral artery (MCA) or internal carotid artery (ICA) steno-occlusive disease. The aim of this study was to evaluate the hemodynamic state in patients with steno-occlusive disease of ICA or MCA on the base of MRI/MRA and acetazolamide (ACZ)-challenged Tc-99m ECD brain perfusion SPECT findings. METHODS: An analysis of 68 patients who underwent MRI/MRA and ACZ-challenged Tc-99m ECD brain perfusion SPECT was performed. We divided these patients into two groups - MCA and ICA steno-occlusions. RESULTS: The cerebrovascular reserve (CVR) was impaired in 18 of 32 (56.3%) MCA disease patients (20 stenosis and 12 occlusions), and in 19 of 36 (52.8%) ICA disease patients (20 stenosis and 16 occlusion). The CVR was impaired in 22 of 28 (78.6%) occlusive patient, whereas in 15 of 40 (37.5%) stenotic patient (p< 0.01). The insular lesion was more commonly involved in the occlusion group (54%) than in the stenosis group (15%) (p< 0.01). CONCLUSIONS: There was no difference in CVR between MCA and ICA steno-occlusion groups. Incidence of impaired CVR was higher in occlusion group than stenosis group.
