Outcomes of Second-Line Chemotherapy for Advanced Non-Small Cell Lung Cancer in One Institution.
- Author:
Seok Jeong LEE
1
;
Hyun Ju KANG
;
Seo Woo KIM
;
Yon Ju RYU
;
Jin Hwa LEE
;
Yookyung KIM
;
Jung Hyun CHANG
Author Information
- Publication Type:Original Article
- Keywords: Age Groups; Carcinoma, Non-Small-Cell Lung; Drug Therapy; Survival
- MeSH: Age Factors; Carcinoma, Non-Small-Cell Lung*; Drug Therapy*; Humans; Mortality; Multivariate Analysis; Retrospective Studies; Smoke; Smoking
- From:Tuberculosis and Respiratory Diseases 2014;77(1):13-17
- CountryRepublic of Korea
- Language:English
- Abstract: BACKGROUND: This study analyzed the negative prognostic factors in patients who received second-line chemotherapy for advanced inoperable non-small cell lung cancer (NSCLC). METHODS: We retrospectively reviewed the records of 137 patients with inoperable stage III-IV NSCLC who received second-line chemotherapy. The effects of clinical parameters on survival were analyzed and the hazard ratios (HR) for mortality were identified by a Cox regression analysis. RESULTS: Sex, age older than 65 years, smoking history, cell type, T-stage, best response to first-line chemotherapy and first-line chemotherapy regimen were significant negative predictors in univariate analysis. The multivariate analysis showed that patients older than 65 years (HR, 1.530; 95% confidence interval [CI], 1.020-2.297), advanced T stage (T4 vs. T1; HR, 2.273; 95% CI, 1.010-5.114) and non-responders who showed progression with first-line chemotherapy (HR, 1.530; 95% CI, 1.063-2.203) had higher HR for death. CONCLUSION: The age factor, T stage and responsiveness to first-line chemotherapy were important factors in predicting the outcome of patients with advanced NSCLC who received second-line chemotherapy. The results may help to predict outcomes for these patients in the future.
