Deficiencies in proteins C and S in a patient with idiopathic portal hypertension accompanied by portal vein thrombosis.
10.3350/kjhep.2010.16.2.176
- Author:
Sena HWANG
1
;
Do Young KIM
;
Minju KIM
;
Young Eun CHON
;
Hyun Jung LEE
;
Young Nyun PARK
;
Jun Yong PARK
;
Sang Hoon AHN
;
Kwang Hyub HAN
;
Chae Yoon CHON
Author Information
1. Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea. dyk1025@yuhs.ac
- Publication Type:Case Report ; English Abstract
- Keywords:
Portal hypertension;
Thrombosis;
Protein C deficiency;
Protein S deficiency
- MeSH:
Humans;
Hypertension, Portal/complications/*diagnosis/pathology;
Male;
*Portal Vein;
Protein C Deficiency/*complications;
Protein S Deficiency/*complications;
Tomography, X-Ray Computed;
Venous Thrombosis/complications/*diagnosis/pathology;
Young Adult
- From:The Korean Journal of Hepatology
2010;16(2):176-181
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Portal vein thrombosis (PVT) is an uncommon cause of presinusoidal portal hypertension. Among various hepatoportal disorders, noncirrhotic portal hypertension conditions such as idiopathic portal hypertension (IPH) are considered to have a close relation with PVT. PVT is known to have several predisposing conditions, including infection, malignancies, and coagulation disorders. There is growing interest and recognition that deficiencies in proteins C and S are associated with a hypercoagulable state. These deficiencies are regarded as key factors of systemic hypercoagulability and recurrent venous thromboembolism. We report the case of a 19-year-old male diagnosed as IPH with PVT and combined deficiencies in proteins C and S.
