Effect of Smoking on Osteoporotic Vertebral Fracture in Postmenopausal Women.
- Author:
Sang Pil YOON
1
;
Seung Hwan LEE
;
Byeong Mun PARK
;
Kyung Sub SONG
;
Geun JANG
;
Beom Seok LEE
;
Hwan Mo LEE
;
Seong Hwan MOON
Author Information
- Publication Type:Original Article
- Keywords: Osteoporotic vertebral fracture; smoking; bone mineral density
- MeSH: Bone Density; Female; Hip Fractures; Humans; Logistic Models; Obesity; Osteoporosis; Retrospective Studies; Risk Factors; Smoke*; Smoking*; Spine
- From:Journal of Korean Society of Spine Surgery 2016;23(1):1-6
- CountryRepublic of Korea
- Language:Korean
- Abstract: STUDY DESIGN: A retrospective study. OBJECTIVES: To evaluate the association between smoking and osteoporotic vertebral fractures (OVFs) in postmenopausal women. SUMMARY OF LITERATURE REVIEW: Several studies have examined the relationship of smoking with hip fractures, but few studies have analyzed the relationship of smoking with spine fractures in women thus far. MATERIALS AND METHODS: This study considered 1255 postmenopausal women aged 50 years and older (enrollment from April 2008 to January 2009) from 62 study sites in a nationwide hospital. The amount of smoking was calculated in pack-years. Further, OVFs were diagnosed using a semi-quantitative method. To analyze the relationship between smoking and OVFs, we used a paired t-test, a χ2-test, and a binary logistic regression analysis. RESULTS: The past history of smoking was 7.2% in the patient group and 4.3% in the control group (p=0.025). The mean pack-years of smoking was 0.34 in the control group and 0.62 in the patient group (p=130). The mean T-score in the lumbar bone mass density (BMD) was –1.64 in the control group and –2.19 in the patient group (p=0.409). Smoking was a risk factor of vertebral fractures in postmenopausal women (odd's ratio=1.68, 95% confidence interval=1.020–2.759, p=0.042) irrespective of the lumbar BMD and the medical treatment for osteoporosis and obesity. CONCLUSIONS: Smoking is a risk factor for osteoporotic vertebral fractures in postmenopausal women independently without regard to lumbar BMD. Therefore, cessation of smoking is important for the prevention of OVFs in postmenopausal women.
