Hypercalcemia Refractory to Pamidronate Associated with Metastatic Calcifications in Multiple Organs.
- Author:
Gi Bum BAE
1
;
Jung Su EUN
;
Na Ri KIM
;
Churl Hyun IM
;
Eon Jeong NAM
;
Young Mo KANG
Author Information
1. Department of Internal Medicine, Kyungpook National University School of Medicine, Daegu, Korea. ymkang@knu.ac.kr
- Publication Type:Case Report
- Keywords:
Hypercalcemia;
Metastatic;
Calcification;
Pamidronate;
Zoledronic acid
- MeSH:
Bone and Bones;
Congenital Abnormalities;
Diphosphonates;
Fibrosis;
Humans;
Hypercalcemia*;
Imidazoles;
Osteitis Deformans;
Wounds and Injuries
- From:Korean Journal of Medicine
2013;85(5):545-550
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Paget's disease of bone (PDB) is a disorder featuring high-level bone turnover associated with the presence of disorganized and immature bone tissue with excessive levels of fibrosis. The risk of deformity is very high. The etiology of PDB is not well understood, but includes both genetic and environmental factors among which is bone trauma. Hypercalcemia can occur as a complication of PDB in patients who are immobilized and dehydrated. However, to date, no case of severe hypercalcemia with metastatic calcifications in multiple organs has been reported in any PDB patient. The drugs of choice for treatment of PDB are bisphosphonates. These drugs effectively suppress bone turnover. Patients with extensive PDB may require higher doses of bisphosphonates, and acquired resistance to a particular bisphosphonate may be overcome by use an alternative drug. Here, we report a case of suspicion of PDB. The patient presented with hypercalcemia and metastatic calcifications and his condition improved dramatically after treatment with zoledronic acid.
