Incidence, Predictors, and Clinical Outcomes of New-Onset Diabetes Mellitus after Percutaneous Coronary Intervention with Drug-Eluting Stent.
10.3346/jkms.2017.32.10.1603
- Author:
Kyeong Hyeon CHUN
1
;
Eui IM
;
Byeong Keuk KIM
;
Dong Ho SHIN
;
Jung Sun KIM
;
Young Guk KO
;
Donghoon CHOI
;
Yangsoo JANG
;
Myeong Ki HONG
Author Information
1. Division of Cardiology, Department of Internal Medicine, Severance Cardiovascular Hospital, Yonsei University College of Medicine, Seoul, Korea. mkhong61@yuhs.ac
- Publication Type:Original Article
- Keywords:
Diabetes Mellitus;
Percutaneous Coronary Intervention;
Coronary Artery Disease
- MeSH:
Body Mass Index;
Coronary Artery Disease;
Diabetes Mellitus*;
Drug-Eluting Stents*;
Fasting;
Glucose;
Hemoglobin A, Glycosylated;
Humans;
Hydroxymethylglutaryl-CoA Reductase Inhibitors;
Incidence*;
Myocardial Infarction;
Percutaneous Coronary Intervention*;
Retrospective Studies;
Stents;
Thrombosis;
Triglycerides
- From:Journal of Korean Medical Science
2017;32(10):1603-1609
- CountryRepublic of Korea
- Language:English
-
Abstract:
We investigated the incidence, predictors, and long-term clinical outcomes of new-onset diabetes mellitus (DM) after percutaneous coronary intervention (PCI) with drug-eluting stent (DES). A total of 6,048 patients treated with DES were retrospectively reviewed and divided into three groups: 1) known DM (n = 2,365; fasting glucose > 126 mg/dL, glycated hemoglobin > 6.5%, already receiving DM treatment, or previous history of DM at the time of PCI); 2) non-DM (n = 3,247; no history of DM, no laboratory findings suggestive of DM at PCI, and no occurrence of DM during follow-up); and 3) new-onset DM (n = 436; non-DM features at PCI and occurrence of DM during follow-up). Among 3,683 non-DM patients, 436 (11.8%) patients were diagnosed with new-onset DM at 3.4 ± 1.9 years after PCI. Independent predictors for new-onset DM were high-intensity statin therapy, high body mass index (BMI), and high level of fasting glucose and triglycerides. The 8-year cumulative rate of major adverse cardiac events (a composite of cardiovascular death, myocardial infarction, stent thrombosis, or any revascularization) in the new-onset DM group was 19.5%, which was similar to 20.5% in the non-DM group (P = 0.467), but lower than 25.0% in the known DM group (P = 0.003). In conclusion, the incidence of new-onset DM after PCI with DES was not low. High-intensity statin therapy, high BMI, and high level of fasting glucose and triglycerides were independent predictors for new-onset DM. Long-term clinical outcomes of patients with new-onset DM after PCI were similar to those of patients without DM.
