An Immunohistochemical Study of Oncogene Interaction in Skin Tumors.
- Author:
Hoon HUR
;
Jin Gyun AHN
;
Young Suck RO
;
Jae Hong KIM
- Publication Type:Original Article
- Keywords:
p53 Protein;
Squaimous Cell Carcinoma;
Immunohistochernistry
- MeSH:
Carcinoma, Basal Cell;
Down-Regulation;
Epidermal Growth Factor;
Humans;
Immunohistochemistry;
Keratosis, Actinic;
Oncogenes*;
Phenotype;
S Phase;
Skin*
- From:Korean Journal of Dermatology
1994;32(6):962-970
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: Alteration of a wide variety of cellular oncogerms have now been implieated in the causation of many human cancers. However, genetic studies have indicated that an abnormality of a single gene is usually insufficient to elicit the fug transformed phenotype and that two or more genetic leaions may be necessary for this to occur. OBJECT: The purpose of this study is to examine the possibity of oncogene interaction which might be involved in the pathogenesis of human skin tugois. METHODS: The expression of the epidermal growth factor rattor(EGFR), c-jun protein, c-fos protein and p53 protein was assessed in frozen and corresgoAhng paraffin-embedded sections of 37 separate skin lesions (6 actinic keratoses, 6 squamo is ell carcinomas and 25 basal cell carcinomas using immunohistochemistry. RESULTS: Substantial number of the p53 positive cases were negative for c-fos, in contrast to normal tissue, which was p53 negative and c-fos positive. The negative correlation between p53 and c-fos staining was statistically significant(P<0.005). CONCLUSION: Although p53 appeared to have lost its normal role of regulatory early S phase protein in some lesions, in others high levels of p53 were assocated with underexpression of c-fos, reflecting the diversity of c-fos oncogene and the possible down regulation of c-fos expression by high levels of p53 protein.
