Effectiveness of Preoperative Intravitreal Bevacizumab Injections in Pars Plana Vitrectomy for Proliferative Diabetic Retinopathy.
10.3341/jkos.2009.50.8.1221
- Author:
Gang Seok JEON
1
;
Jae Ryong HAN
;
Woo Ho NAM
;
Ha Kyoung KIM
Author Information
1. Department of Ophthalmology, Kangnam Sacred Heart Hospital, College of Medicine, Hallym University, Seoul, Korea. ophkim@hallym.or.kr
- Publication Type:Original Article
- Keywords:
Bevacizumab (Avastin(R));
Pars Plana Vitrectomy;
Proliferative diabetic retinopathy
- MeSH:
Antibodies, Monoclonal, Humanized;
Diabetic Retinopathy;
Eye;
Hemorrhage;
Humans;
Incidence;
Postoperative Hemorrhage;
Retrospective Studies;
San Francisco;
Visual Acuity;
Vitrectomy;
Vitreous Hemorrhage;
Bevacizumab
- From:Journal of the Korean Ophthalmological Society
2009;50(8):1221-1225
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: To evaluate the efficacy of preoperative intravitreal bevacizumab (Avastin(R); Genetech, San Francisco, CA, USA) injections of pars plana vitrectomy (PPV) for proliferative diabetic retinopathy (PDR). METHODS: Thirty patients (30 eyes) who underwent PPV for treatment of PDR and received a preoperative intravitreal bevacizumab injection of 1.25 mg were retrospectively analyzed. The study group (group 1, 30 patients, 30 eyes) was compared with a control group (group 2, 29 patients, 30 eyes and matched with the study group for preoperative parameters) who underwent PPV without preoperative intravitreal bevacizumab injection. RESULTS: In both groups, visual acuity improved but there was no statistical significance. Intraoperative vitreous hemorrhage occurred in 14 eyes (46.7%) from group 1 and 11 eyes (36.7%) from group 2. There was no statistical significance of intraoperative bleeding occurrence (p=0.3). Postoperative vitreous hemorrhage occurred in 4 eyes from group 1 and 14 eyes from group 2. The group 1 had a lower incidence of postoperative hemorrhage than group 2 (p=0.005). CONCLUSIONS: Preoperative intravitreal bevacizumab injection appears effective in decreasing early postoperative vitreous hemorrhage and maybe technically helpful in PPV for PDR.
