Chromosomal Aberration in Fractionated Radiotherapy.
- Author:
Hyong Geun YUN
1
;
Sung Whan HA
Author Information
1. Department of Therapeutic Radiology, Dankook University College of Medicine, Chungnam, Korea.
- Publication Type:Original Article
- Keywords:
Biological dosimetry;
Chromosomal aberration;
Lymphocyte;
Fractionated radiotherapy
- MeSH:
Cervix Uteri;
Chromosome Aberrations*;
Female;
Humans;
Lymphocytes;
Pelvis;
Radiotherapy*
- From:The Journal of the Korean Society for Therapeutic Radiology and Oncology
1998;16(2):115-123
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: This study was tried to evaluate the effect of the partial body fractionated irradiation on the frequency of chromosomal aberration. MATERIALS AND METHODS: In three patients with uterine cervix carcinoma, chromosomal aberrations were analyzed during fractionated external beam radiotherapy. Radiation field included whole pelvis and total dose was 5040 cGy in 28 fractions. RESULTS: The values of the frequency of dicentrics and rings (Ydr) in pre- irradiated peripheral lymphocytes in three patients were 0.0060, 0.0000, and 0.0029, respectively. The frequency of dicentrics and rings, estimated during the course of radiotherapy, increased with radiation dose and best fitted to the linear equation, Ydr=7.31x10(-5) D(cGy)+1.45x10(-2). The frequency of dicentrics and rings among the cells with dicentric and/or ring (Qdr) also showed increasing tendency and best fitted to the linear equation, Qdr= 1.01x10(-4) D(cGy)+1.04. CONCLUSION: Ydr increased linearly with radiation dose in the dose range of our study, and Qdr showed increasing tendency with dose.
