A case of hyperosmolar nonketotic coma associated with androgen deprivation therapy in prostate cancer.
- Author:
Eun Yeong HONG
1
;
Seok Won LEE
;
Jun Goo KANG
;
Chul Sik KIM
;
Sung Hee IHM
;
Hyung Joon YOO
;
Seong Jin LEE
Author Information
1. Department of Internal Medicine, Hallym University College of Medicine, Chuncheon, Korea. leesj@hallym.ac.kr
- Publication Type:Case Report
- Keywords:
Androgen antagonist;
Diabetes mellitus;
Hyperosmolar nonketotic coma;
Prostate cancer
- MeSH:
Aged;
Anilides;
Blood Glucose;
Cardiovascular Diseases;
Coma;
Diabetes Mellitus;
Fasting;
Gonadotropin-Releasing Hormone;
Humans;
Insulin;
Leuprolide;
Nitriles;
Organothiophosphorus Compounds;
Prostate;
Prostatic Neoplasms;
Tosyl Compounds
- From:Korean Journal of Medicine
2010;79(5):573-576
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
During advanced prostate cancer, androgen deprivation therapy (ADT) using gonadotropin-releasing hormone and antiandrogen is an effective treatment modality. Recently, it has been reported that ADT may result in diabetes mellitus (DM), metabolic syndrome, and cardiovascular disease. Here, we report the first case in the literature of new-onset DM and hyperosmolar nonketotic coma (HNKC) associated with ADT. A 69-year-old man visited our hospital because of altered mentality. The patient had been taking leuprolide and bicalutamide for metastatic prostate cancer for the past 4 months. In laboratory tests, new-onset DM with HNKC was diagnosed. The patient was immediately treated with intravenous hydration and insulin therapy, and recovered without sequela. Because ADT can cause DM, or rarely HNKC, it is necessary to monitor fasting blood glucose and lipid profiles carefully while ADT is performed.
