Metronidazole Induced Encephalopathy with Peripheral Polyneuropathy in Patient with Spinal Cord Injury.
- Author:
Gi Hoon HWANG
1
;
Young Joo SIM
;
Ho Joong JEONG
;
Ghi Chan KIM
;
Bae Wook SIN
;
Ju Ho JUNG
Author Information
- Publication Type:Case Report
- Keywords: Metronidazole; Encephalopathy; Spinal cord injury
- MeSH: Adult; Diffusion; Female; Gait; Humans; Magnetic Resonance Imaging; Metronidazole; Paraplegia; Peripheral Nerves; Peripheral Nervous System Diseases; Polyneuropathies; Seizures; Spinal Cord; Spinal Cord Injuries; Stress, Psychological
- From:Korean Journal of Spine 2012;9(1):44-48
- CountryRepublic of Korea
- Language:English
- Abstract: Metronidazole may produce a number of neurologic side effects including peripheral neuropathy, seizure, encephalopathy. We experienced neurological side effects of metronidazole. The 32-year-old female patient with spinal cord injury was diagnosed as encephalophathy and peripheral polyneuropathy resulting from complication of metronidazole. It was difficult to diagnose at first glance using clinical findings because of paraplegia due to spinal cord injury. But through magnetic resonance imaging with diffusion weighted imaging and electrophysiologic study, the patient showed to have characteristic abnormalities that of a person suffering from metronidazole-induced encephalopathy and peripheral polyneuropathy. Whether the symptoms were caused by a peripheral nerve lesion or MIE, the patient's paraplegia prevented to appear other symptoms, such as ataxic gait and seizure, from manifesting. In such case as this, an active differentiated diagnosis is crucial.
