The Role of Chemotherapy in Anaplastic Astrocytoma Patients.
10.3340/jkns.2012.51.4.199
- Author:
Sung Kwon KIM
1
;
Jin Wook KIM
;
Yong Hwy KIM
;
Tae Min KIM
;
Se Hoon LEE
;
Chul Kee PARK
Author Information
1. Department of Neurosurgery, Seoul National University College of Medicine, Seoul, Korea. nsckpark@paran.com
- Publication Type:Original Article
- Keywords:
Anaplastic astrocytoma;
Chemotherapy;
Procarbazine;
Lomustine;
Vincristine;
PCV;
Nimustine-cisplatin
- MeSH:
Astrocytoma;
Clinical Protocols;
Humans;
Lomustine;
Male;
Procarbazine;
Retrospective Studies;
Vincristine
- From:Journal of Korean Neurosurgical Society
2012;51(4):199-202
- CountryRepublic of Korea
- Language:English
-
Abstract:
OBJECTIVE: This retrospective study was performed to evaluate the role of chemotherapy in the management of patients with anaplastic astrocytoma (AA). METHODS: We compared the survival outcome among the 3 different treatment protocol groups in a single institution. A total of 86 patients (39 men and 47 women) with newly diagnosed AA after surgery were analyzed. Among them, 31 patients (36.0%) were treated with radiotherapy only (RT Group), 30 patients (34.9%) were treated with nimustine-cisplatin chemotherapy before RT (ACNU-CDDP group), and 25 patients (29.1%) were treated with procarbazine, lomustine and vincristine (PCV) chemotherapy after radiotherapy (PCV group). RESULTS: The median survival was 14.0, 30.0 and 72.0 months in RT, ACNU-CDDP, and PCV group, respectively and showed significant differences (RT vs. ACNU-CDDP; p=0.039, RT vs. PCV; 0.002, ACNU-CDDP vs. PCV; 0.045). PCV group showed less toxicity rate (5 patients; 20%) than ACNU-CDDP group (12 patients; 40%), while only 3 patients (9.6%) in RT group experienced grade 3 or 4 toxicities. CONCLUSION: An application of chemotherapy before or after radiotherapy is beneficial in prolonging the survival of patients with AA. Adjuvant PCV chemotherapy after radiotherapy is recommendable.
